🧬 NAD⁺: Research Overview

For Laboratory, Scientific, and Educational Research Only

NAD⁺ (Nicotinamide Adenine Dinucleotide) is a vital coenzyme present in every living cell. It plays a central role in energy metabolism, mitochondrial function, and cellular repair. In laboratory and preclinical research, NAD⁺ is widely studied for its involvement in redox reactions, DNA‑repair pathways, and age‑related biological processes. Its broad systemic relevance makes it a cornerstone molecule in metabolic and longevity research.

⭐ Key Areas of Scientific Interest

Preclinical and mechanistic studies have explored NAD⁺ for its potential involvement in:

Cellular Energy & Mitochondrial Function

• Essential cofactor in ATP production through oxidative phosphorylation

• Central role in redox cycling (NAD⁺/NADH balance)

• Research into mitochondrial efficiency, resilience, and biogenesis

DNA Repair & Genomic Stability

• Required for PARP enzyme activity involved in DNA‑damage repair

• Interest in NAD⁺ depletion during cellular stress

• Studies examining its role in maintaining genomic integrity

Sirtuin Activation & Longevity Pathways

• NAD⁺ is a required substrate for sirtuin enzymes (SIRT1–SIRT7)

• Research into sirtuin‑mediated effects on metabolism, inflammation, and aging

• Exploration of NAD⁺’s role in cellular stress resistance

Metabolic Regulation

• Influence on glucose and lipid metabolism

• Studies examining NAD⁺ levels in metabolic‑health models

• Interest in circadian‑rhythm regulation through NAD⁺‑dependent enzymes

Neuroprotective & Cognitive Research

• Investigation into neuronal energy balance

• Potential involvement in axonal repair and neuroinflammatory pathways

• Research into age‑related cognitive decline in experimental models