🧬 FOXO4‑DRI: Research Overview

For Laboratory, Scientific, and Educational Research Only, COA

FOXO4‑DRI is a synthetic peptide designed to interfere with the interaction between the transcription factor FOXO4 and the protein p53. This interaction plays a key role in cellular senescence — the process by which damaged or aged cells stop dividing but remain metabolically active. In laboratory and preclinical research, FOXO4‑DRI is studied for its potential to selectively target senescent cells while sparing healthy ones, making it a prominent compound in the field of senolytic research.

⭐ Key Areas of Scientific Interest

Preclinical studies have explored FOXO4‑DRI for its potential involvement in:

Cellular Senescence & Senolytic Activity

• Disruption of FOXO4–p53 binding in senescent cells

• Induction of apoptosis in senescent cells while minimizing effects on non‑senescent cells

• Interest in its role in clearing accumulated senescent cells in experimental models

Aging & Longevity Research

• Studies examining tissue rejuvenation following senescent‑cell clearance

• Potential improvements in organ function in aged laboratory models

• Exploration of FOXO4‑DRI’s role in age‑related biological pathways

Tissue Repair & Regeneration

• Research into enhanced tissue recovery after senescent‑cell removal

• Potential influence on muscle, skin, and organ‑system regeneration

• Interest in its effects on stem‑cell niches and cellular turnover

Oxidative Stress & DNA Damage Response

• Modulation of pathways involved in cellular stress responses

• Studies exploring interactions with p53‑mediated DNA‑damage signaling

• Potential relevance to chronic inflammation and metabolic decline